Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.

@article{Shimada1985AntitumorAO,
  title={Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors.},
  author={Shizuo Shimada and Osamu Yano and Hiroko Inoue and Etsuro Kuramoto and T Fukuda and H. Yamamoto and Tetsuro Kataoka and Tohru Tokunaga},
  journal={Journal of the National Cancer Institute},
  year={1985},
  volume={74 3},
  pages={
          681-8
        }
}
MY-1, a fraction extracted from BCG and composed of 70.0% DNA and 28.0% RNA, was examined for its antitumor activity against 9 different syngeneic mouse tumors. Tumor regression was induced in almost all of the mice bearing any of five kinds of solid tumors by repeated intralesional injections of 100 micrograms MY-1. When cells of some tumors were inoculated intradermally together with MY-1, tumor growth was suppressed, lung metastases were inhibited, and the survival times of mice bearing 1 of… 
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