Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.

@article{Hori1977AntitumorAO,
  title={Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.},
  author={Seiji Hori and Masataka Shirai and Shinji Hirano and Toshikazu Oki and Takashi Inui and Shigeru Tsukagoshi and Masaaki Ishizuka and Tadayoshi Takeuchi and Hamao Umezawa},
  journal={Gan},
  year={1977},
  volume={68 5},
  pages={685-90}
}
New anthracycline antibiotics have been isolated from the culture of Streptomyces galilaeus MA144-M1. Among 14 anthracycline compounds, aclacinomycin-A showed the strongest activity in inhibiting leukemia L-1210 and had lower toxicity than others. Antitumor activity of aclacinomycin-A against leukemia L-1210 and P-388, solid sarcoma-180, and lymphosarcoma… CONTINUE READING