Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.

@article{Kudo1980AntitumorAO,
  title={Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.},
  author={Takeaki Kudo and Tomio Narisawa and Shichisaburo Abo},
  journal={Gan},
  year={1980},
  volume={71 2},
  pages={260-4}
}
The effect of treatment with indomethacin on methylazoxymethanol-induced rat large bowel carcinomas was investigated. Eight-week-old male Donryu rats received an intraperitoneal injection of 20 mg/kg body weight of methylazoxymethanol acetate once a week for 6 weeks. Fifteen rats were sacrificed at the 25th week. It was confirmed that the incidence of large bowel tumors (adenocarcinomas) was 60% and the mean number of tumors per tumor-bearing rat was 2.0. The other rats (23 approximately 30… CONTINUE READING
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