Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts.

@article{Cattaruzza2011AntitumorAO,
  title={Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts.},
  author={Lara Cattaruzza and Dolores Fregona and Maurizio Mongiat and Luca Ronconi and Ambrogio Fassina and Alfonso Colombatti and Donatella Aldinucci},
  journal={International journal of cancer},
  year={2011},
  volume={128 1},
  pages={206-15}
}
Among the nonplatinum antitumor drugs, gold(III)-dithiocarbamato derivatives have recently attracted considerable attention due to their strong in vitro and in vivo antiproliferative activity and reduced renal toxicity. Some of them, namely [AuCl(2) (DMDT)] (compound 1) and [AuBr(2) (ESDT)] (compound 2), have shown to be highly active against the androgen-resistant prostate cancer cell lines PC3 and DU145, both inhibiting cell proliferation in a dose-dependent way, and are more active than the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Groundbreaking gold(III) anticancer agents. Drug Discov Today 2009;14:1075–6. C an ce r T he ra py 214 Antitumor activity of gold(III) compounds in prostate cancer

  • D Aldinucci, L Ronconi, D. Fregona
  • Int. J. Cancer:
  • 2011

On the medicinal chemistry of gold complexes as anticancer drugs

  • I. Ott
  • Coord Chem Rev 2009;253:1670–81
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…