Antitumor activity of gamma-interferon in ascitic and solid tumor models of human ovarian cancer.

@article{Malik1991AntitumorAO,
  title={Antitumor activity of gamma-interferon in ascitic and solid tumor models of human ovarian cancer.},
  author={Shafayat Ali Malik and Richard Graham Knowles and Nick East and Danielle Lando and Gordon Stamp and Frances R. Balkwill},
  journal={Cancer research},
  year={1991},
  volume={51 24},
  pages={
          6643-9
        }
}
We have investigated the action of recombinant human gamma-interferon (rHuIFN-gamma) against human ovarian cancer xenografts growing as ascites or as bulky solid i.p. tumors in nude mice. Both forms of the disease responded to i.p. rHuIFN-gamma with significant increases in mouse survival time, and in 2 of 3 ascitic models the mice were cured of peritoneal disease. The activity of rHuIFN-gamma was dose and schedule dependent, and xenografts derived from 3 different patients showed a… CONTINUE READING