Antitumor activity of fungal metabolites: verrucarin beta-9, 10-epoxides.
@article{Jarvis1978AntitumorAO, title={Antitumor activity of fungal metabolites: verrucarin beta-9, 10-epoxides.}, author={Bruce B. Jarvis and G. Patrick Stahly and C. Curtis}, journal={Cancer treatment reports}, year={1978}, volume={62 10}, pages={ 1585-6 } }
Verrucarins A (4) and B (5) and verrucarin A acetate, in vivo antileukemic inactive fungal metabolites, have been oxidized with m-chloroperoxybenzoic acid to give verrucarin beta-9,10-epoxides which show high in vivo activity against P388 mouse leukemia.
3 Citations
Structure of roridin J, a new macrocyclic trichothecene from Myrothecium verrucaria.
- ChemistryThe Journal of antibiotics
- 1980
Sir: During a continuing program to isolate and chemically modify mycotoxins1), we have isolated and identified a new macrocyclic trichothecene from the fermentation of Myrothecium verrucaria (ATCC…
Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor
- BiologyPloS one
- 2014
Verrucarin A is a potent and selective SMI that blocks SRC-3 function through an indirect mechanism, unlike other SRC SMIs characterized by the laboratory that directly bind to SRCs.
Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential
- Biology, ChemistryArchives of Toxicology
- 2017
It is hoped that this review will show how trichothecene bioactivities can be exploited to generate therapies against pathogens and cancer.