• Corpus ID: 36847862

Antitumor activity of fungal metabolites: verrucarin beta-9, 10-epoxides.

  title={Antitumor activity of fungal metabolites: verrucarin beta-9, 10-epoxides.},
  author={Bruce B. Jarvis and G. Patrick Stahly and C. Curtis},
  journal={Cancer treatment reports},
  volume={62 10},
Verrucarins A (4) and B (5) and verrucarin A acetate, in vivo antileukemic inactive fungal metabolites, have been oxidized with m-chloroperoxybenzoic acid to give verrucarin beta-9,10-epoxides which show high in vivo activity against P388 mouse leukemia. 
Structure of roridin J, a new macrocyclic trichothecene from Myrothecium verrucaria.
Sir: During a continuing program to isolate and chemically modify mycotoxins1), we have isolated and identified a new macrocyclic trichothecene from the fermentation of Myrothecium verrucaria (ATCC
Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor
Verrucarin A is a potent and selective SMI that blocks SRC-3 function through an indirect mechanism, unlike other SRC SMIs characterized by the laboratory that directly bind to SRCs.
Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential
It is hoped that this review will show how trichothecene bioactivities can be exploited to generate therapies against pathogens and cancer.