Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis.

@article{Yong2009AntitumorAO,
  title={Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis.},
  author={Yeonjoong Yong and Soon Young Shin and Young Han Lee and Yoongho Lim},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 15},
  pages={4367-71}
}
An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Plants and cervical cancer: an overview.

Expert opinion on investigational drugs • 2013

Similar Papers

Loading similar papers…