Antitumor activity of decoy oligodeoxynucleotides targeted to NF-kappaB in vitro and in vivo.

@article{Wang2010AntitumorAO,
  title={Antitumor activity of decoy oligodeoxynucleotides targeted to NF-kappaB in vitro and in vivo.},
  author={Tao Wang and Qinghua Li and Gang-Ping Hao and Jing Zhai},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2010},
  volume={11 1},
  pages={
          193-200
        }
}
BACKGROUND Nuclear factor-kappaB (NF-kappaB), a transcription factor, is abundantly expressed in many tumors and regulates many tumor-relative genes such as c-myc and caspase-8, which NF-kappaB-mediated genes activation serves as an anti-tumor pathway by regulating expression of these tumor-relative genes. Given the important roles of these genes in tumor control, the present study was to test the hypothesis that NF-kappaB decoy ODNs transfected into tumor cells in vitro and in vivo might… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Design and characterization of decoy oligonucleotides containing locked nucleic acids

  • KR Cutroneo, SL White, JF Chiu
  • Nucleic Acids Res
  • 2006

NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts

  • N Tomita, R Morishita, HY Lan
  • Gene Ther
  • 2000