Antitumor activity of bevacizumab in combination with capecitabine and oxaliplatin in human colorectal cancer xenograft models.

@article{Yanagisawa2009AntitumorAO,
  title={Antitumor activity of bevacizumab in combination with capecitabine and oxaliplatin in human colorectal cancer xenograft models.},
  author={Mieko Yanagisawa and Kaori Fujimoto-Ouchi and Keigo Yorozu and Yoriko Yamashita and Kazushige Mori},
  journal={Oncology reports},
  year={2009},
  volume={22 2},
  pages={
          241-7
        }
}
To understand the mechanisms of the effects of combination treatments, we established animal models showing antitumor activity of bevacizumab as a monotherapy and in combination with capecitabine or capecitabine and oxaliplatin and measured thymidine phosphorylase (TP) and vascular endothelial growth factor (VEGF) levels. Tumor-inoculated nude mice were treated with bevacizumab, capecitabine, and oxaliplatin, alone or in combination, after tumor growth was confirmed and volume and microvessel… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study.

Leonard B Saltz, Stephen Clarke, +10 authors Jim Cassidy
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008

Pharmacology and pharmacodynamics of Bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies

Gerber H-P, N Ferrara
  • Cancer Res
  • 2005

The role of thymidine phosphorylase , an angiogenic enzyme , in tumor progression

S Akiyama, T Hurukawa, +4 authors M Haraguchi
  • Cancer Sci
  • 2004

Vascular endothelial growth factor as a target for anticancer therapy

N Ferrara
  • Oncologist
  • 2004

Effect of antivascular endotherial growth factor treatment on the intratumoral uptake of CPT11

H Wilders, G Guetens, +5 authors AT vanOosterom
  • Br J Cancer
  • 2003