Antitumor activity of amino acid derivatives in the primary screening.

  title={Antitumor activity of amino acid derivatives in the primary screening.},
  author={K. Fukushima and S. Toyoshima},
  volume={66 1},
  • K. Fukushima, S. Toyoshima
  • Published 1975
  • Biology, Medicine
  • Gan
  • Approximately 350 amino acid derivatives were synthesized and tested for antitumor activity in four tumor systems. The effect on life prolongation and tumor growth was examined using mouse leukemia SR-61, Ehrlich ascites carcinoma, ascites sarcoma-180, and rat ascites hepatoma (AH-60C). Among these 350 derivatives, 29 compounds were found to be significantly effective in prolongation of the median life-span and inhibitory effect on tumor growth in the primary screening. Among these 29 compounds… CONTINUE READING
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