Antitumor activity of amino acid derivatives in the primary screening.

K. Fukushima; S. Toyoshima

DOI:10.20772/CANCERSCI1959.66.1_29

Corpus ID: 11324319

Antitumor activity of amino acid derivatives in the primary screening.

@article{Fukushima1975AntitumorAO,
  title={Antitumor activity of amino acid derivatives in the primary screening.},
  author={K. Fukushima and S. Toyoshima},
  journal={Gan},
  year={1975},
  volume={66 1},
  pages={
          29-36
        }
}

K. Fukushima, S. Toyoshima

Published 1975

Biology, Medicine

Gan

Approximately 350 amino acid derivatives were synthesized and tested for antitumor activity in four tumor systems. The effect on life prolongation and tumor growth was examined using mouse leukemia SR-61, Ehrlich ascites carcinoma, ascites sarcoma-180, and rat ascites hepatoma (AH-60C). Among these 350 derivatives, 29 compounds were found to be significantly effective in prolongation of the median life-span and inhibitory effect on tumor growth in the primary screening. Among these 29 compounds… CONTINUE READING

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