Antitumor activity of a sulfated polysaccharide from Enteromorpha intestinalis targeted against hepatoma through mitochondrial pathway

@article{Wang2013AntitumorAO,
  title={Antitumor activity of a sulfated polysaccharide from Enteromorpha intestinalis targeted against hepatoma through mitochondrial pathway},
  author={Xuxia Wang and Ying Hsien Chen and Jing-jie Wang and Zhenxiong Liu and Shuguang Zhao},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={1641-1647}
}
A sulfated polysaccharide (EI-SP), extracted from Enteromorpha intestinalis that is a kind of algae, is found to have anticancer activity. This study was designed to investigate the anti-tumor effect of EI-SP on human hepatoma HepG2 cell line and its possible mechanisms. An MTT assay showed that EI-SP could specifically inhibit the growth of human hepatoma HepG2 cells in a dose-dependent manner. Analysis by flow cytometry indicated that the apoptosis of tumor cells increased after treatment… CONTINUE READING
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