Antitumor activity of a phenoxazine compound, 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis, and necrosis

Abstract

Abstract Purpose. We studied the antitumor activity of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one (Phx), which was synthesized by the reactions of 2-amino-5-methylphenol with bovine hemoglobin, on human B cell lymphoblastoid cell lines, P3HR-1 and Raji derived from African Burkitt's lymphoma, and the human T cell lymphoblastoid cell line Molt-4… (More)
DOI: 10.1007/s00432-002-0352-3

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@article{KoshibuKoizumi2002AntitumorAO, title={Antitumor activity of a phenoxazine compound, 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis, and necrosis}, author={Junko Koshibu-Koizumi and Masato Akazawa and T. Iwamoto and Mayumi Takasaki and Fumiko Mizuno and Ryoji Kobayashi and A. Abe and Akihiko Tomoda and Motoharu Hamatake and Ryosuke Ishida}, journal={Journal of Cancer Research and Clinical Oncology}, year={2002}, volume={128}, pages={363-368} }