Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation.

@article{Ashizawa2011AntitumorAO,
  title={Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation.},
  author={Tadashi Ashizawa and Haruo Miyata and Hidee Ishii and Chie Oshita and Kenji Matsuno and Yoshiaki Masuda and Toshio Furuya and Tadashi Okawara and M. Otsuka and Naohisa Ogo and Akira Asai and Yasuto Akiyama},
  journal={International journal of oncology},
  year={2011},
  volume={38 5},
  pages={1245-52}
}
Signal transducer and activator of transcription (STAT)3, a member of a family of DNA-binding molecules mediating numerous physiological and oncogenic signaling pathways, is a novel target in cancer cells which show high phosphorylation of STAT3. Recently, we identified a novel small-molecule inhibitor of STAT3 dimerization, STX-0119, as a cancer therapeutic. We investigated the mechanisms responsible for the antitumor activity in vitro and in vivo through numerous biochemical and biological… CONTINUE READING
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