Antitumor activity of a kinesin inhibitor.

  title={Antitumor activity of a kinesin inhibitor.},
  author={Roman Sakowicz and Jeffrey T. Finer and Christophe Beraud and Anne Moon Crompton and Evan Lewis and Alex Fritsch and Yan Lee and John Mak and Robert Moody and Rebecca Turincio and John C Chabala and Paul A Gonzales and Stephanie Roth and Steve Weitman and K. Wood},
  journal={Cancer research},
  volume={64 9},
Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays an essential role in formation of a bipolar mitotic spindle and is required for cell cycle progression through mitosis. We identified a potent inhibitor of KSP, CK0106023, which causes mitotic arrest and growth inhibition in several human tumor cell… CONTINUE READING


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Methods and compositions utilizing quinazolinones

  • JT Finer, G Bergnes, B Feng, WW Smith, JC. Chabala
  • PCT Int. Appl. WO 01/030768:
  • 2001
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