Antitumor activity of Type I and Type III interferons in BNL hepatoma model

@article{Abushahba2010AntitumorAO,
  title={Antitumor activity of Type I and Type III interferons in BNL hepatoma model},
  author={Walid Abushahba and Murugabaskar Balan and Ismael Castaneda and Yao Yuan and Kenneth R. Reuhl and Elizabeth S. Raveche and Andrew de la Torre and Ahmed Lasfar and Sergei V. Kotenko},
  journal={Cancer Immunology, Immunotherapy},
  year={2010},
  volume={59},
  pages={1059-1071}
}
Hepatocellular carcinoma (HCC) occurs most commonly secondary to cirrhosis due to chronic hepatitis C or B virus (HCV/HBV) infections. Type I interferon (IFN-α) treatment of chronic HCV/HBV infections reduces the incidence of HCC in cirrhotic patients. However, IFN-α toxicity limits its tolerability and efficacy highlighting a need for better therapeutic treatments. A recently discovered type III IFN (IFN-λ) has been shown to possess antiviral properties against HCV and HBV in vitro. In phase I… CONTINUE READING

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