Corpus ID: 77912

Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models.

@article{Breistl1999AntitumorAO,
  title={Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models.},
  author={K. Breist{\o}l and J. Balzarini and M. Sandvold and F. Myhren and M. Martinsen and E. De Clercq and O. Fodstad},
  journal={Cancer research},
  year={1999},
  volume={59 12},
  pages={
          2944-9
        }
}
The antineoplastic efficacy of P-4055, a 5'-elaidic acid (C18:1, unsaturated fatty acid) ester of cytarabine, a nucleoside antimetabolite frequently used in the treatment of hematological malignancies, was examined in several in vivo models for human cancer. In initial dose-finding studies in nude mice, the efficacy of P-4055 was highest when using schedules with repeated daily doses. In a Raji Burkitt's lymphoma leptomeningeal carcinomatosis model in nude rats, the control cytarabine- and… Expand
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