Antitumor activity of NPB001-05, an orally active inhibitor of Bcr-Abl tyrosine kinase.

@article{Wagh2011AntitumorAO,
  title={Antitumor activity of NPB001-05, an orally active inhibitor of Bcr-Abl tyrosine kinase.},
  author={V. Wagh and Prabha B. Mishra and Arvind D Thakkar and V. Shinde and Somesh Sharma and M. Padigaru and K. Joshi},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={
          1349-64
        }
}
Scientists are constantly searching for phytochemical compounds with anti-cancer activity. In this study, activity of plant extract NPB001-05 from Piper betle was tested on human chronic myelogenous leukemia (CML) xenograft models. NPB001-05 was active when dosed orally (500 mg/kg) once or twice a day in xenograft tumor models. NPB001-05 showed activity to T315I tumor xenograft, where imatinib failed to show antitumor activity. NPB001-05 showed no relevant toxicity in animal models during 2… Expand
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References

SHOWING 1-10 OF 76 REFERENCES
In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00
  • 108
  • PDF
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma
  • 59
  • PDF
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
  • 898
  • PDF
Plant-derived protein tyrosine kinase inhibitors as anticancer agents.
  • 31
Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer.
  • 110
Plant-derived anticancer agents.
  • 522
...
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2
3
4
5
...