• DOI:10.2741/E338
Corpus ID: 38113784

Antitumor activity of NPB001-05, an orally active inhibitor of Bcr-Abl tyrosine kinase.

@article{Wagh2011AntitumorAO,
  title={Antitumor activity of NPB001-05, an orally active inhibitor of Bcr-Abl tyrosine kinase.},
  author={V. Wagh and Prabha B. Mishra and Arvind D Thakkar and V. Shinde and Somesh Sharma and M. Padigaru and K. Joshi},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={
          1349-64
        }
}

• V. Wagh, Prabha B. Mishra, +4 authors K. Joshi
• Published 2011
• Medicine, Biology
• Frontiers in bioscience

Scientists are constantly searching for phytochemical compounds with anti-cancer activity. In this study, activity of plant extract NPB001-05 from Piper betle was tested on human chronic myelogenous leukemia (CML) xenograft models. NPB001-05 was active when dosed orally (500 mg/kg) once or twice a day in xenograft tumor models. NPB001-05 showed activity to T315I tumor xenograft, where imatinib failed to show antitumor activity. NPB001-05 showed no relevant toxicity in animal models during 2… Expand

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