Antitumor activity of L-canavanine against L1210 murine leukemia.

  title={Antitumor activity of L-canavanine against L1210 murine leukemia.},
  author={Michael H. L. Green and Traci L Brooks and John Mendelsohn and Stephen B. Howell},
  journal={Cancer research},
  volume={40 3},
We have made a preliminary assessment of the antitumor activity of the arginine analog, L-canavanine, in leukemic mice. This analog is known to substitute for arginine in protein biosynthesis in many prokaryotic and eukaryotic systems. Previous studies with cells grown in vitro indicated that canavanine caused a marked inhibition of DNA synthesis and… CONTINUE READING