Antitumor activity of HPA3P through RIPK3-dependent regulated necrotic cell death in colon cancer

@article{Cho2018AntitumorAO,
  title={Antitumor activity of HPA3P through RIPK3-dependent regulated necrotic cell death in colon cancer},
  author={Eugene Cho and Jong-kook Lee and Eunji Park and C. Seo and T. Luchian and Yoonkyung Park},
  journal={Oncotarget},
  year={2018},
  volume={9},
  pages={7902 - 7917}
}
The antimicrobial peptide HPA3 shows anticancer activity in gastric cancer and leukaemia. However, how HPA3 exerts its anticancer activity, as well as whether it also exhibits activity in other cancers, remains unknown. Therefore, the aim of this study was to evaluate the anticancer activity of HPA3 and its analogues in colon cancer and to elucidate the mechanisms responsible for this activity. HPA3P decreased cell viability, whereas HPA3 and HPA3P2 did not decrease cell viability in colon… Expand
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