Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization.

@article{Asai1998AntitumorAO,
  title={Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization.},
  author={T. Asai and K. Kurohane and S. Shuto and H. Awano and A. Matsuda and H. Tsukada and Y. Namba and S. Okada and N. Oku},
  journal={Biological & pharmaceutical bulletin},
  year={1998},
  volume={21 7},
  pages={
          766-71
        }
}
We previously synthesized the 5'-O-diacylphosphatidyl derivative of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC), a novel antitumor nucleoside, and observed it to have a high antitumor activity. Since this compound is readily incorporated into liposomal membranes, we liposomalized the compound using a formulation for conventional and long-circulating liposomes, and investigated the antitumor activity of liposomal 5'-O-dipalmitoylphosphatidyl CNDAC (DPP-CNDAC). Long… Expand
18 Citations
Sapacitabine for cancer
Liposomalized oligopeptides in cancer therapy.
Anticancer therapy using glucuronate modified long-circulating liposomes.
  • Oku
  • Medicine
  • Advanced drug delivery reviews
  • 1999
Pharmacokinetics of lipid‐drug conjugates loaded into liposomes
...
1
2
...