Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death.

@article{Ogbourne2004AntitumorAO,
  title={Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death.},
  author={Steven M Ogbourne and Andreas Suhrbier and Brad Jones and Sarah-Jane Cozzi and Glen M Boyle and Melanie S. Morris and Devi McAlpine and Jenny P. Johns and Tania M Scott and Kirsty P Sutherland and Joy M Gardner and Thuy Thi Le and Aleksandra Lenarczyk and James H. Aylward and Peter G Parsons},
  journal={Cancer research},
  year={2004},
  volume={64 8},
  pages={2833-9}
}
Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rates and extended treatment schedules. Here, we describe the preclinical activity of a novel topical chemotherapeutic agent for the treatment of skin cancer, 3-ingenyl angelate… CONTINUE READING
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