Antitumor activity of (-)-alpha-bisabolol-based thiosemicarbazones against human tumor cell lines.

@article{DaSilva2010AntitumorAO,
  title={Antitumor activity of (-)-alpha-bisabolol-based thiosemicarbazones against human tumor cell lines.},
  author={Alan Patricio Da Silva and Manuele V. Martini and Cec{\'i}lia M A de Oliveira and S{\'i}lvio Cunha and Jo{\~a}o Ernesto de Carvalho and Ana L{\'u}cia Tasca Gois Ruiz and Cleuza Conceiç{\~a}o da Silva},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 7},
  pages={
          2987-93
        }
}
Trypanocidal and cytotoxic evaluation of synthesized thiosemicarbazones as potential drug leads against sleeping sickness
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The thiosemicarbazones 2–5 that displayed significant anti-trypanosomal and cytoxicity activities are suggested to have anti-neoplastic and anti-cancer activities.
Thiosemicarbazones as a Potent Anticancer Agents and Their Modes of Action.
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Present findings show that, in U937 cells, 1‐indanone thiosemicarbazones coordinated to palladium(II) were more cytotoxic than those complexed with platinum(II), although the latter were found to be more selective for leukemic cells suggesting that they are promising compounds with potential therapeutic application against hematological malignancies.
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Antitrypanosomal Activity of Novel Benzaldehyde-Thiosemicarbazone Derivatives from Kaurenoic Acid †
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The results show that the structural modifications accomplished enhanced the antitrypanosomal activity of these compounds.
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In contrast to other thiosemicarbazones with potent antiproliferative activity, Fe chelation and mobilization rather than free radical generation played a significant role in the cytotoxic effects of the current ligands.
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