Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.

@article{Song2008AntitumorAA,
  title={Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.},
  author={Dongweon Song and Raghothama Chaerkady and Aik Choon Tan and Elena Garc{\'i}a-Garc{\'i}a and Anuradha Nalli and Ana Su{\'a}rez-Gauthier and Fernando L{\'o}pez-R{\'i}os and Xian Feng Zhang and Anna Solomon and Jeffrey H Tong and Margaret P. Read and Christian Fritz and Antonio J. Jimeno and Akhilesh Pandey and Maartje Hidalgo},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 10},
  pages={3275-84}
}
Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in most cancers. However, the role and mode of action of Hsp90 inhibitors in pancreatic cancer has not been studied. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in pancreatic cancer and to determine the biological effects of the agent. In vitro, we show that pharmacologic inhibition of Hsp90 by IPI-504… CONTINUE READING
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