Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo.

@article{Odwyer1994AntitumorAA,
  title={Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo.},
  author={Peter J. O'dwyer and James D. Moyer and Matthew Suffness and Steadman D. Harrison and Richard L. Cysyk and Thomas C. Hamilton and Jacqueline Plowman},
  journal={Cancer research},
  year={1994},
  volume={54 3},
  pages={724-9}
}
Aphidicolin, an inhibitor of DNA polymerases alpha and delta, is cytotoxic in vitro against tumor cells. The poor solubility of aphidicolin has led to the development of aphidicolin glycinate (AG; NSC 303812), a water soluble ester currently in early clinical trials. The antitumor activity of AG was investigated in a series of transplantable murine tumors in vivo. The drug demonstrated activity against the i.p. implanted B16 melanoma, producing maximum increased life spans of 75% following i.p… CONTINUE READING