Antitumor activities of newly synthesized N4-acyl-1-beta-D-arabinofuranosylcytosine.

  title={Antitumor activities of newly synthesized N4-acyl-1-beta-D-arabinofuranosylcytosine.},
  author={Minoru Aoshima and Shigeru Tsukagoshi and Yoichi Sakurai and J I Oh-ishi and Toshimasa Ishida},
  journal={Cancer research},
  volume={36 8},
New derivatives of 1-beta-D-arabinofuranosylcytosine were synthesized and their antitumor activities were tested against mouse leukemia L1210. Among the 50 compounds investigated, a series of N4-acyl derivatives with long-chain saturated fatty acids were found to be highly active. The most active derivatives were N4-stearoly-1-beta-D-arabinofuranosylcytosine, which was administered in the form of suspension, and N4-behenoyl-1-beta-D-arabinofuranosylcytosine given in the form of solution. They… CONTINUE READING
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