• Corpus ID: 89537489

Antitumor Extrolites Produced by Penicillium Species

@inproceedings{Nicoletti2008AntitumorEP,
  title={Antitumor Extrolites Produced by Penicillium Species},
  author={Rosario Nicoletti and Maria Letizia Ciavatta and Elisabetta Buommino and Maria Antonietta Tufano},
  year={2008}
}
Biodiversity is increasingly exploited worldwide for the finding of new pharmaceuticals. In relation to a competitive aptitude developed in many and diverse environments, microorganisms are able to produce secondary metabolites with cytotoxic and antiproliferative properties that are valuable in the perspective of antitumor drug discovery. Particularly, fungal species in the genus Penicillium represent a prolific source of biologically active extrolites that in some cases have already disclosed… 

Figures from this paper

Penicillium spp.: prolific producer for harnessing cytotoxic secondary metabolites

Endophytic secondary metabolites from the genus Penicillium with a relevant role as cytotoxic agents with potential applications as leads for anticancer drugs are outlined.

Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin

An overview of data published over the past 25 years concerning the production and biological activities of secondary metabolites of marine strains belonging to these genera, and their relevance as prospective drugs is offered.

Patenting Penicillium strains.

An overview of the patents released in the last four years in agriculture, bioremediation, and in several industrial fields for the production of biofuels, food, cosmetics and pharmaceuticals is proposed for an exhaustive appreciation of the potential cues offered to inventors by these fungi.

Antagonistic aptitude and antiproliferative properties on tumor cells of fungal endophytes from the Astroni Nature Reserve, Italy

An investigation on fungal endophytes from 28 species of trees and shrubs thriving at the Astroni Nature Reserve near Naples, Italy finds inhibition of mycelial growth was confirmed for about 60% of the culture extracts prepared from these bioactive strains, and was mostly correlated to an antiproliferative activity in human tumor cell cultures.

Bioactive Compounds Produced by Strain of Penicillium sp.

During our search for bioactive compounds from fungi, the terrestrial Penicilliumsp.KH Link 1809 isolate KHMM was fermented on large scale using solid rice medium. After harvesting, working up and

Endophytism of Penicillium Species in Woody Plants

The available data on occurrence, biocenotic role, production and bioactivities of secondary metabolites of Penicillium strains which have been isolated as endophytes from woody plants are reviewed in the aim to introduce the state of the art to researchers involved in this particular field.

Endophytic fungi associated with Taxus fuana (West Himalayan Yew) of Pakistan: potential bio-resources for cancer chemopreventive agents

The endophytic fungi studied are capable of producing pharmacologically active natural compounds and isolates derived from the wood of Taxus fuana should be prioritized for the isolation and characterization of bioactive constituents.

3‐O‐Methylfunicone, a metabolite produced by Penicillium pinophilum, modulates ERK1/2 activity, affecting cell motility of human mesothelioma cells

3‐O‐methylfunicone (OMF), a secondary metabolite produced by Penicillium pinophilum, affects cell proliferation and motility in a variety of human solid tumours and whether OMF has the ability to arrest cell division and motability in a human mesothelioma cell line is demonstrated.

3‐O‐methylfunicone, from Penicillium pinophilum, is a selective inhibitor of breast cancer stem cells

Anti‐proliferative effects of 3‐O‐methylfunicone (OMF), a metabolite from Penicillium pinophilum, were investigated on human breast cancer MCF‐7 cells and cancer stem cells selected as mammospheres derived from MCF•7s.

References

SHOWING 1-10 OF 327 REFERENCES

Bioprospecting for antagonistic Penicillium strains as a resource of new antitumor compounds

The study showed that a quick screening of fungal isolates can be operated by assaying their fungal extracts on tumor cells directly, with the ensuing advantage of restricting the work required for the characterization of the bioactive compounds to a reduced number of promising strains.

Cytotoxic metabolites produced by a fungal strain from a Sargassum alga.

It is found that a strain of Penicillium waksmanii Zaleski OUPS-N133 separated from the brown alga Sargassum ringgoldianum produces two novel compounds, pyrenocines D and E, along with the known compounds, two pyrenOCines A and B, and three dioxopiperazine derivatives.

Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge.

Three new indole alkaloids, shearinines D, E, and F (1-3) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge, and they induce apoptosis in human leukemia HL-60 cells and inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar.

Mycophenolic acid: antiviral and antitumor properties.

It is reported that mycophenolic acid exhibits in vitro and in vivo antiviral activity, and significantly inhibits the growth of a broad spectrum of transplantable solid tumors in mice.

Antitumor antibiotics produced by Penicillium stipitatum Thom.

The other crystalline antibiotic identified as duclauxin was isolated from the filtrate of the above-mentioned strain and showed an inhibitory effect on EHRLICH ascites carcinoma, lymphadenoma L-5178 and sarcoma 37.

Methylenolactocin, a Novel Antitumorial Antibiotic from Penicillium sp.

An a-methylene-y-lactone antibiotic named methylenolactocin (1) from the culture broth of a strain No. 24-4, which was isolated from a soil sample collected in a farmyard in the city of Takatsuki, Osaka prefecture, Japan, showed selective antimicrobial activity, especially against Gram-positive bacteria.

Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus.

The compound exhibits promising activities in several mammalian and viral test systems, in particular a highly selective cytostatic activity against murine leukemic lymphoblasts and the ability to protect human T cells against the cytopathic effects of HIV-1.

Production and fungitoxic activity of Sch 642305, a secondary metabolite of Penicillium canescens

Production of fungitoxic extrolites was evaluated in culture filtrates of several isolates belonging to Penicillium canescens and P. janczewskii that showed some extent of inhibitory activity against the plant pathogenic fungus Rhizoctonia solani, and another extrolite recently characterized from a P. verrucosum strain was detected.

Berkelic acid, a novel spiroketal with selective anticancer activity from an acid mine waste fungal extremophile.

Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of the novel spiroketal, berkelic acid 1, and of the known gamma-pyrone, spiciferone A 4, and the characterization of these compounds are reported here.
...