Antitumor Activity of Vinyl Polymer Immobilized 5-Fluorouracils through Organosilicon-Amine Spacer Groups via Urea Bonds

@article{Ohya1992AntitumorAO,
  title={Antitumor Activity of Vinyl Polymer Immobilized 5-Fluorouracils through Organosilicon-Amine Spacer Groups via Urea Bonds},
  author={Y. Ohya and T. Nakao and T. Ouchi and Takeshi Inoi and K. Fukushima and T. Tashiro},
  journal={Journal of Macromolecular Science, Part A},
  year={1992},
  volume={29},
  pages={503-515}
}
  • Y. Ohya, T. Nakao, +3 authors T. Tashiro
  • Published 1992
  • Materials Science
  • Journal of Macromolecular Science, Part A
  • Abstract The homopolymerization of vinyl monomer immobilized 5-fluorouracils (5FU) through organosilicon-amine spacer groups via urea bonds (KY-20) and the copolymerization of KY-20 with vinyl monomer were carried out by a radical technique to give the homopolymer [Poly(KY-20)] and copolymer [Poly(KY-20/vinyl monomer)], respectively. The antitumor activities of Poly(KY-20) and Poly(KY-20/vinyl monomer) were tested against p388 lymphocytic leukemia by intraperitoneal (i.p.) transplantation/i.p… CONTINUE READING