Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

  title={Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma},
  author={Alessia Ligresti and Aniello Schiano Moriello and Katarzyna Starowicz and Isabelle Matias and Simona Pisanti and Luciano De Petrocellis and Chiara Laezza and Giuseppe Portella and Maurizio Bifulco and Vincenzo Di Marzo},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1375 - 1387}
Δ9-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, and assessed whether there is any advantage in using Cannabis extracts (enriched in either cannabidiol or THC) over pure cannabinoids. Results obtained in a panel of tumor cell lines clearly… 
The antitumor activity of cannabidiol on lung cancer cell lines A549 and H1299: the role of apoptosis
Evaluated the cytotoxic activity of cannabidiol and its effect on the process of programmed cell death in lung cancer cell lines and found that CBD treatment led to a dose-dependant apoptosis increase in p53 positive A549 cells.
The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
Mechanisms by which CBD, and other plant-derived cannabinoids inefficient at activating cannabinoid receptors, inhibit tumor cell viability, invasion, metastasis, angiogenesis, and the stem-like potential of cancer cells are discussed.
Cannabidiol and Other Phytocannabinoids as Cancer Therapeutics
A better understanding of the circadian rhythmicity of the ECS could enhance the efficacy of a therapy with cannabinoids by optimization of the timing of the administration, as has already been reported for some of the canonical chemotherapeutics.
Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Cannabidiol, the second most abundant plant-derived cannabinoid, in combination with Δ9-THC is tested and it is suggested that the addition of cannabidiole may improve the overall effectiveness of Δ9 -THC in the treatment of glioblastoma in cancer patients.
A Review of the Therapeutic Antitumor Potential of Cannabinoids.
A large number of cannabinoid compounds have been discovered, developed, and used to study the effects of cannabinoids on cancers in model systems, but few clinical trials have been conducted on the use of cannabinoids in the treatment of cancers in humans.
Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas
Cannabinoids, in particular the non-psychoactive CBD, may be promising tools in combination therapy for breast and prostate cancer, due to their direct antitumor effects, their ability to improve the efficacy of conventional antitumors drugs and their usefulness as palliative treatment.
Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis
The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.
Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer
Cannabinoids may be an effective adjunct for the treatment of pancreatic cancer, and data on the anticancer effectiveness of various cannabinoid formulations, treatment dosing, precise mode of action, and clinical studies are lacking.
Cannabidiol (CBD) Oil Does Not Display an Entourage Effect in Reducing Cancer Cell Viability in vitro
It was found that pure CBD was as potent or more potent at reducing cancer cell viability as the most potent oil tested, suggesting that there is no “entourage” effect under these specific in vitro conditions.
Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis
The data indicate that cannabinoids modulate endometrial cancer cell death, and further support the evaluation of CBD and CBD-rich extracts for the potential treatment of endometricrial cancer, particularly, that has become non-responsive to common therapies.


Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
Evaluating the in vitro antiproliferative ability of cannabidiol (CBD), a nonpsychoactive cannabinoid compound, on U87 and U373 human glioma cell lines suggests a possible application of CBD as an antineoplastic agent.
Established and potential therapeutic applications of cannabinoids in oncology
The use of cannabinoids should be continued in the areas indicated, and further studies are needed to evaluate other potential uses in clinical oncology.
Cannabinoid receptor as a novel target for the treatment of prostate cancer.
The results suggest that WIN-55,212-2 or other non-habit-forming cannabinoid receptor agonists could be developed as novel therapeutic agents for the treatment of prostate cancer.
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.
The data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous Prolactin action at the level of prolactin receptor.
Cannabinoids and cancer.
  • N. Kogan
  • Biology
    Mini reviews in medicinal chemistry
  • 2005
Today, a wide array of cancer cell lines that are affected is known, and some mechanisms involved have been elucidated, and a wide range of therapeutic properties of cannabinoids are known.
A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
It is shown that the CB(1) and theCB(2) receptor are expressed in normal skin and skin tumors of mice and humans and support a new therapeutic approach for the treatment of skin tumors.
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism
The results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified.
Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response.
It is demonstrated that the human breast cancer cell lines MCF-7 and MDA-MB-231 and the mouse mammary carcinoma 4T1 express low to undetectable levels of cannabinoid receptors, CB1 and CB2, and that these cells are resistant to Delta9-THC-induced cytotoxicity.