Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

@article{Ligresti2006AntitumorAO,
  title={Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma},
  author={Alessia Ligresti and Aniello Schiano Moriello and Katarzyna Starowicz and Isabelle Matias and Simona Pisanti and Luciano De Petrocellis and Chiara Laezza and Giuseppe Portella and Maurizio Bifulco and Vincenzo Di Marzo},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={318},
  pages={1375 - 1387}
}
Δ9-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, and assessed whether there is any advantage in using Cannabis extracts (enriched in either cannabidiol or THC) over pure cannabinoids. Results obtained in a panel of tumor cell lines clearly… 
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