Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

  title={Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma},
  author={A. Ligresti and A. S. Moriello and K. Starowicz and I. Matias and S. Pisanti and L. De Petrocellis and C. Laezza and G. Portella and M. Bifulco and V. Di Marzo},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1375 - 1387}
  • A. Ligresti, A. S. Moriello, +7 authors V. Di Marzo
  • Published 2006
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • Δ9-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, and assessed whether there is any advantage in using Cannabis extracts (enriched in either cannabidiol or THC) over pure cannabinoids. Results obtained in a panel of tumor cell lines clearly… CONTINUE READING
    The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
    • 52
    • Highly Influenced
    • PDF
    Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis
    • 2
    • Highly Influenced
    • PDF
    Cannabinoids as therapeutic agents in cancer: current status and future implications
    • 109
    • PDF
    Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
    • 48
    • PDF


    Publications referenced by this paper.
    Established and potential therapeutic applications of cannabinoids in oncology
    • 145
    Cannabinoid receptor as a novel target for the treatment of prostate cancer.
    • 204
    • PDF
    The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.
    • 379
    • PDF
    Cannabinoids and cancer.
    • 52
    • PDF
    A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
    • 385
    • Highly Influential
    • PDF
    Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
    • 349
    • PDF
    Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism
    • 114
    • PDF