Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

@article{Ligresti2006AntitumorAO,
  title={Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma},
  author={Alessia Ligresti and Aniello Schiano Moriello and Katarzyna Starowicz and Isabelle Matias and Simona Pisanti and Luciano De Petrocellis and Chiara Laezza and Giuseppe Portella and Maurizio Bifulco and Vincenzo Di Marzo},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={318},
  pages={1375 - 1387}
}
Δ9-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, and assessed whether there is any advantage in using Cannabis extracts (enriched in either cannabidiol or THC) over pure cannabinoids. Results obtained in a panel of tumor cell lines clearly… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
TLDR
Evaluating the in vitro antiproliferative ability of cannabidiol (CBD), a nonpsychoactive cannabinoid compound, on U87 and U373 human glioma cell lines suggests a possible application of CBD as an antineoplastic agent. Expand
Established and potential therapeutic applications of cannabinoids in oncology
TLDR
The use of cannabinoids should be continued in the areas indicated, and further studies are needed to evaluate other potential uses in clinical oncology. Expand
Cannabinoid receptor as a novel target for the treatment of prostate cancer.
TLDR
The results suggest that WIN-55,212-2 or other non-habit-forming cannabinoid receptor agonists could be developed as novel therapeutic agents for the treatment of prostate cancer. Expand
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.
TLDR
The data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous Prolactin action at the level of prolactin receptor. Expand
Cannabinoids and cancer.
  • N. M. Kogan
  • Biology, Medicine
  • Mini reviews in medicinal chemistry
  • 2005
TLDR
Today, a wide array of cancer cell lines that are affected is known, and some mechanisms involved have been elucidated, and a wide range of therapeutic properties of cannabinoids are known. Expand
A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
TLDR
The hypothesis that the combination of THC and CBD increases clinical efficacy while reducing adverse events is supported, and prospects for future application of whole cannabis extracts in neuroprotection, drug dependency, and neoplastic disorders are examined. Expand
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
TLDR
It is shown that the CB(1) and theCB(2) receptor are expressed in normal skin and skin tumors of mice and humans and support a new therapeutic approach for the treatment of skin tumors. Expand
Δ-9-Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response1
TLDR
It is demonstrated that the human breast cancer cell lines MCF-7 and MDA-MB-231 and the mouse mammary carcinoma 4T1 express low to undetectable levels of cannabinoid receptors, CB1 and CB2, and that these cells are resistant to Δ9-THC-induced cytotoxicity. Expand
Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1.
TLDR
The data suggest that the specific targeting of VR1 by endogenous cannabinoids or synthetic molecules offers attractive opportunities for the development of novel potent anticancer drugs. Expand
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism
TLDR
The results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. Expand
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