Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.

  title={Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.},
  author={Maria Carolina B. Tuma and Asra Malikzay and Xiaohu Ouyang and David Surguladze and James Rodger Fleming and Stan Mitelman and Margarita C{\'a}mara and Bridget C. Finnerty and Jacqueline Doody and Eugene Lvovich Piatnitski Chekler and Paul Kussie and James R. Tonra},
  journal={Translational oncology},
  volume={3 5},
Microtubules are a well-validated target for anticancer therapy. Molecules that bind tubulin affect dynamic instability of microtubules causing mitotic arrest of proliferating cells, leading to cell death and tumor growth inhibition. Natural antitubulin agents such as taxanes and Vinca alkaloids have been successful in the treatment of cancer; however, several limitations have encouraged the development of synthetic small molecule inhibitors of tubulin function. We have previously reported the… CONTINUE READING

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