Antitumor Activity of BOF‐A2, a New 5‐Fluorouracil Derivative

@inproceedings{Fujii1989AntitumorAO,
  title={Antitumor Activity of BOF‐A2, a New 5‐Fluorouracil Derivative},
  author={Setsuro Fujii and Masakazu Fukushima and Yuji Shimamoto and Hideyuki Ohshimo and Takeshi Imaoka and Tetsuhiko Shirasaka},
  booktitle={Japanese journal of cancer research : Gann},
  year={1989}
}
A compound containing both CNDP (3-cyano-2,6-dihydroxypyridine), an inhibitor of 5-fluorouracil (5-FU) degradation, and EM-FU (1-ethoxymethyl-5-fluorouracil), a masked form of 5-FU, was synthesized and named BOF-A2 (3-[3-(6-benzoyloxy-3-cyano-2-pyridyloxycarbonyl)benzoyl]-1-ethoxy methyl-5- fluorouracil). The antitumor activity of BOF-A2 was investigated in sarcoma-180-bearing mice and Yoshida sarcoma-bearing rats. The ED50 (the dose for 50% inhibition) values of BOF-A2 were 25 mg/kg against… CONTINUE READING

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