Antitumor Activity of β-Cyclodextrin Polymer−Camptothecin Conjugates

@inproceedings{Cheng2004AntitumorAO,
  title={Antitumor Activity of β-Cyclodextrin Polymer−Camptothecin Conjugates},
  author={Jianjun Cheng and Kay T. Khin and Mark E Davis},
  year={2004}
}
Antitumor activity of linear, β-cyclodextrin polymer (CDP)−camptothecin (CPT) conjugates (HGGG6, LGGG10, HG6, and HGGG10) is investigated in nude mice bearing human LS174T colon carcinoma tumors. These conjugates differ in polymer molecular mass [97 kDa (H) or 35 kDa (L)], CDP−CPT linker structure [glycine (G) or triglycine (GGG)], and CPT loading [ca. 6 wt % (6) or 10 wt % (10)]. Maximum tolerable doses (MTDs) of the three conjugates, LGGG10, HG6, and HGGG10, are determined to be 36, 9, and 9… CONTINUE READING