Antitumor Activity and Preliminary Drug Disposition Studies on Chartreusin ( NSC 5159 ) 1

Abstract

SUMMARY Chartmeusin has exhibited significant therapeutic activity against three experimental mouse tumors (ascitic P388, Li 210 leukemia, and Bi 6 melanoma) when tumor cells were inoculated i.p. and drug was administered i.p. In further testing against P388 leukemia, no activity was observed when drug was administered p.o., s.c., or i.v. Chartneusin was… (More)

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