Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus.

@article{Akihisa2005AntitubercularAA,
  title={Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus.},
  author={Toshihiro Akihisa and Scott G Franzblau and Harukuni Tokuda and Masaaki Tagata and Motohiko Ukiya and Tsunetomo Matsuzawa and Koichi Metori and Yumiko Kimura and Takashi Suzuki and Ken Yasukawa},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 6},
  pages={1117-9}
}
Seven sterols (1-7) and eight polyisoprenepolyols (8-15), isolated from the non-saponifiable lipid fraction of the dichloromethane extract of an edible mushroom, Hypsizigus marmoreus (Buna-shimeji), were tested for their antitubercular activity against Mycobacterium tuberculosis strain H37Rv using the Microplate Alamar Blue Assay (MABA). Six sterols (2-7) and two polyisoprenepolyols (8, 12) showed a minimum inhibitory concentration (MIC) in the range of 1-51 microg/ml, while the others (1, 9-11… CONTINUE READING