Antitubercular Diazine Carboxamides.

  title={Antitubercular Diazine Carboxamides.},
  author={E. F. Rogers and William J. Leanza and H. J. Becker and Alexander R Matzuk and R. C. O'neill and Arthur J. Basso and Gustav A Stein and Morris Solotorovsky and Francis J. Gregory and Karl Pfister},
  volume={116 3010},
The Brønsted Acid/Base Character of the NN and NN Bonds
  • J. Bartmess
  • Chemistry
    PATAI'S Chemistry of Functional Groups
  • 2019
Mini Review Study of Antitubercular Drugs of Nicotinamide, Thioisonicotinamide and Pyrazinamide Derivatives
A brief discussion about nicotinamide, thioisonicotinamide and pyrazinamide analogues for the better and effect TB treatment particular against resistance mycobacterium strains is discussed.
The Medicinal Chemistry of Tuberculosis Chemotherapy
This chapter explores the medicinal chemistry efforts that gave rise to current frontline and second-line drugs in global use today and attempts to comprehensively summarize ongoing discovery and lead optimization programs being conducted in both the private and the public sector.
Pyrimidines II—Dérivés des acides pyrimidine‐carboxyliques
L'acide pyrimidine-4-carboxylique a ete prepare par oxydation de la 4-methylpyrimidine. Ce produit a ete obtenu par hydrogenolyse de la 2,6-dichloro-, la 6-chloro- et la 2,6 dithiopyrimidine
Antibacterial Agents, Overview
The nitrofurans and the oxazolidinones have found their own niches, principally in the treatment of urinary tract infections and serious gram-positive infections, respectively, and the quinolones retain a prominent position in the armamentarium of antibacterial drugs.
Struktur und Wirkung bei Carbothionamiden
Unter den vielen Stoffen, die in den letzten 15 Jahren auf eine mogliche antituberkulose Wirkung untersucht wurden, fanden sich Substanzen von klinischer Brauchbarkeit innerhalb von drei Gruppen,
Chemie des Isoniazids
Je mehr sich die Erkenntnis durchsetzt, das das Isoniazid (Isonicotinsaurehydrazid) in seiner klinischen Wirkung das Streptomycin ubertrifft, um so notiger ist es, das Isoniazid sowie dessen Derivate


Pyrazinoic Acid Amide-An Agent Active Against Experimental Murine Tuberculosis
Conclusions 1. These data contribute to the importance of niacinamide derivatives as a new class of antituberculosis agents. One of these, pyrazinoic acid amide, is active when administered by
Studies on biological oxidations; the metabolism of lung as determined by a study of slices and ground tissue.
Studies on the metabolism of the lung, as performed in slices and in ground tissue, are presented and show not only destruction of some biochemical activities but also appearance of others normally inhibited in the intact cell.
The effect of nicotinic acid amide on experimental tuberculosis of white mice.
Abstract The oral administration of 0.5 to 0.75 per cent of nicotinic acid amide in the diet will markedly suppress the spread of tuberculosis in experimentally infected mice. This amount of