Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia.

@article{Nibret2009AntitrypanosomalAC,
  title={Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia.},
  author={Endalkachew Nibret and Frank Sporer and Kaleab Asres and Michael Wink},
  journal={The Journal of pharmacy and pharmacology},
  year={2009},
  volume={61 6},
  pages={801-8}
}
OBJECTIVES The objective was to determine the in-vitro effect of extracts from 19 Ethiopian plant species and four pure pyrrolizidine alkaloids on bloodstream forms of Trypanosoma brucei brucei and human leukaemia HL-60 cells. METHODS Crude plant extracts were prepared using methanol and dichloromethane. The alkaloidal extracts from Solanecio angulatus flowers were prepared with and without zinc reduction using the acid-base extraction method. Cell proliferation inhibitory activity of the… CONTINUE READING