Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.

@article{Ngantchou2010AntitrypanosomalAF,
  title={Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.},
  author={Igor Ngantchou and Barth{\'e}l{\'e}my Nyass{\'e} and Colette Denier and Casimir Blonski and V{\'e}ronique Hannaert and Bernd Schneider},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2010},
  volume={20 12},
  pages={
          3495-8
        }
}
In continuation of our study on medicinal plants of Cameroon, stem barks of Polyalthia suaveolens were phytochemically studied. This investigation yielded a new indolosesquiterpene alkaloid, named polysin (1) and four hitherto known alkaloids (2-5). Polysin (1) appeared as a competitive reversible inhibitor (K(i)=10 microM) of phosphofructo kinase (PFK) of Trypanosoma brucei with respect to fructose-6-phosphate (K(i)/K(M)=0.05) and could be used in the design of new trypanocidal drugs. The… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
Four new terpenoids, comprising three nor-secofriedelanes (1-3) and one nor-friedelane (4), were isolated from Galphimia glauca, together with the known flavonol quercetin and the sterolsExpand
Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis.
  • C. Wang
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 1995
TLDR
The African trypanosomes are among the most extensively studied parasitic protozoa to date and can be viewed as attractive targets for antitrypanosomal chemotherapy. Expand
In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.
TLDR
DNA intercalation in combination with protein biosynthesis inhibition, which is the major mode of action of the active alkaloids, could be responsible for the observed trypanocidal and cytotoxic effects. Expand
Polyavolinamide, an indolosesquiterpene alkaloid from Polyathia suaveolens
Abstract A new indolosesquiterpene alkaloid, polyavolinamide, has been identified in the stem of Polyathia suaveolens accompanied by the three previously isolated indolosesquiterpene alkaloids,Expand
In vivo and in vitro effects of extracts from Cassia aubrevillei in onchocerciasis.
TLDR
It is concluded, that "Ganna Ganna" could be a useful adjuvant in the therapy of onchocerciasis and that further evaluation of the drug seems promising. Expand
What Controls Glycolysis in Bloodstream Form Trypanosoma brucei?*
TLDR
Quite unexpectedly, trypanosomes seem to possess a substantial overcapacity of hexokinase, phosphofructokinase and pyruvate kinase, making these “irreversible” enzymes mediocre drug targets. Expand
New approach to screening drugs for activity against African trypanosomes
TLDR
It is reported here how knowledge of trypanosome metabolism has led to a new method for screening drugs againsttrypanosomes that could provide a short-cut to new drugs or drug combinations. Expand
Chemical studies on the annonaceae. Part 9. Indolosesquiterpene and aporphine alkaloids from Greenwayodendron(Polyalthia)suaveolens stem bark. X-Ray crystal stucture of greenwayodendrin-3-one
The isolation and characterization of ten alkaloids, viz. five indolosesquiterpenes and five aporphines, and the triterpene polycarpol from the stem bark of G. suaveolens are reported. Four of theExpand
Alkaloids from Cyrtanthus elatus.
TLDR
The alcoholic extract of the fresh bulbs of Cyrtanthus elatus yielded zephyranthine and 1,2-O-diacetylzephyrants, together with three other known alkaloids, by employment of two-dimensional NMR techniques. Expand
Crinane and lycorane type alkaloids from Zephyranthes citrina.
Eight alkaloids have been isolated from Zephyranthes citrina (Amaryllidaceae). The alkaloid oxomaritidine is reported here for the first time from a natural source. The structure and stereochemistryExpand
...
1
2
3
...