Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.

@article{Bahia2014AntitrypanosomalAO,
  title={Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.},
  author={Maria Terezinha Bahia and Alvaro F S Nascimento and Ana Lia Mazzeti and Luiz Fernando Aar{\~a}o Marques and Karolina Ribeiro Gonçalves and Ludmilla W R Mota and L{\'i}via de Figueiredo Diniz and Ivo Santana Caldas and Andr{\'e} Talvani and David M. Shackleford and Maria Koltun and Jessica L. Saunders and Karen L. White and Ivan Scandale and Susan A. Charman and Eric Chatelain},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 8},
  pages={4362-70}
}
This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a murine model of Chagas disease. Female Swiss mice infected with the Y strain of Trypanosoma cruzi were treated orally once per day with each metabolite at doses of 10 to 100 mg/kg of body weight for a period of 20 days… CONTINUE READING