Antitrypanosomal activities of acetylated bruceines A and C; a structure–activity relationship study


The crude extract of Brucea javanica showed strong in vitro inhibitory activity against Trypanosoma evansi. Among the isolated quassinoids, bruceines A, C, and bruceantinol were found to be the most potent compounds against T. evansi. To gain a deeper understanding of the relationship between the free hydroxyl groups and the activity, several O-acetylated… (More)
DOI: 10.1007/s11418-011-0571-5


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