Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.


The 7-benzylidenenaltrexone (BNTX) derivatives 2a-v, 3a-c, 13a-c, and 14a were synthesized from naltrexone (1) and evaluated for their antitrichomonal activity. The structure-activity-relationship studies found that 4-iodo-BNTX (2g) showed the highest activity (IC50=10.5µM) and the affinity for the opioid receptor was less important for antitrichomonal… (More)
DOI: 10.1016/j.bmc.2017.06.026