Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation.

@article{Anscher2006AntitransformingGF,
  title={Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation.},
  author={Mitchell Steven Anscher and Bradley A. Thrasher and Zahid N. Rabbani and Beverly A Teicher and Zeljko Vujaskovi{\'c}},
  journal={International journal of radiation oncology, biology, physics},
  year={2006},
  volume={65 3},
  pages={876-81}
}
PURPOSE The aim of this study was to determine whether a neutralizing transforming growth factor-beta (TGFbeta) antibody can prevent radiation (RT) induced lung injury. METHODS AND MATERIALS Fractionated and sham right lung irradiation in Fischer 344 rats was delivered to assess the radioprotective effect of the antibodies. Animals were divided into the… CONTINUE READING