Antithyroid effect of a food or drug preservative: 4-hydroxybenzoic acid methyl ester

@article{Rousset1981AntithyroidEO,
  title={Antithyroid effect of a food or drug preservative: 4-hydroxybenzoic acid methyl ester},
  author={Bernard Rousset},
  journal={Experientia},
  year={1981},
  volume={37},
  pages={177-178}
}
4-hydroxybenzoic acid methyl ester (methylparaben) inhibits organification of iodide by isolated hog thyroid cells. The concentration which produces a 50% inhibition was about 2.0×10−4M. A similar inhibition was observed in nonstimulated and TSH- or dibutyryl cyclic AMP-stimulated cells. Neither iodide uptake nor cyclic AMP generation were altered by methylparaben. 
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