Antithymocyte globulin stimulates human hematopoietic progenitor cells.

  title={Antithymocyte globulin stimulates human hematopoietic progenitor cells.},
  author={Andrew Tsao Huang and N G Mold and Shou Feng Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 16},
Antithymocyte globulin (ATG), a horse antihuman thymus antiserum highly effective in the majority of patients with aplastic anemia, was studied for its in vitro effects on hematopoietic progenitor cells. Marrow cells isolated by an immunoadherence technique with the HPCA-1 (human progenitor cell antigen) monoclonal antibody after removal of contaminating T cells and macrophages formed erythroid colonies in methyl cellulose media in the presence of ATG at concentrations of 25-50 micrograms/ml… CONTINUE READING

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