Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets.

@article{Kufrin2003AntithromboticTE,
  title={Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets.},
  author={Dubravka Kufrin and Don E. Eslin and Khalil H Bdeir and J C Murciano and Alice Kuo and Maria Anna Kowalska and Jay L. Degen and Bruce S. Sachais and Douglas B Cines and M. Poncz},
  journal={Blood},
  year={2003},
  volume={102 3},
  pages={926-33}
}
Arterial occlusive disorders are a leading cause of human morbidity. We hypothesized that ectopic expression of fibrinolytic proteins in platelets could be used to favorably alter the hemostatic balance at sites of thrombosis. To test our hypothesis, we directed murine urokinase-type plasminogen activator transgene expression to platelets using a platelet… CONTINUE READING