Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates.

@article{Gruber1991AntithromboticEO,
  title={Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates.},
  author={Andr{\'a}s Gruber and Laurence A. Harker and Stephen R. Hanson and Andrew B Kelly and John H. Griffin},
  journal={Circulation},
  year={1991},
  volume={84 6},
  pages={2454-62}
}
BACKGROUND We have determined in vivo the relative antithrombotic efficacy and hemostatic safety of combining low-dose activated protein C (APC) and urokinase (urinary plasminogen activator, u-PA), two natural proteins that regulate thrombogenesis. METHODS AND RESULTS To model acute thrombotic responses of native blood under conditions of arterial flow, thrombogenic segments of Dacron vascular graft (VG) were incorporated into chronic exteriorized femoral arteriovenous (AV) access shunts in… CONTINUE READING