Antithrombogenic effect of urokinase bound to collagen substrate with bifunctional antibodies

Abstract

In vitro experiments simulating collagen-induced thrombogenesis in arteries damaged during angioplasty demonstrate a marked inhibitory effect of surface-bound urokinase. In contrast to free urokinase, bound enzyme is more effective in preventing platelet aggregation on the collagen surface.

DOI: 10.1007/BF02444301

2 Figures and Tables

Cite this paper

@article{Stepanova2006AntithrombogenicEO, title={Antithrombogenic effect of urokinase bound to collagen substrate with bifunctional antibodies}, author={Irina P Stepanova and M. V. Tsybul'skaya and Sergey P Domogatskii}, journal={Bulletin of Experimental Biology and Medicine}, year={2006}, volume={117}, pages={502-505} }