Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury.

@article{Rehberg2013AntithrombinAV,
  title={Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury.},
  author={Sebastian Rehberg and Yusuke Yamamoto and Linda E. Sousse and Collette C Jonkam and Yong Zhu and Lillian D. Traber and Robert Akers Cox and Donald S. Prough and Daniel Lee Traber and Perenlei Enkhbaatar},
  journal={Critical care medicine},
  year={2013},
  volume={41 12},
  pages={
          e439-46
        }
}
OBJECTIVE To test the hypothesis that restoration of antithrombin plasma concentrations attenuates vascular leakage by inhibiting neutrophil activation through syndecan-4 receptor inhibition in an established ovine model of acute lung injury. DESIGN Randomized controlled laboratory experiment. SETTING University animal research facility. SUBJECTS Eighteen chronically instrumented sheep. INTERVENTIONS Following combined burn and smoke inhalation injury (40% of total body surface area… CONTINUE READING
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