Antithrombin acts as a negative acute phase protein as established with studies on HepG2 cells and in baboons.

@article{Niessen1997AntithrombinAA,
  title={Antithrombin acts as a negative acute phase protein as established with studies on HepG2 cells and in baboons.},
  author={R. W. Niessen and R. Lamping and Patty Micha{\"e}la Jansen and Martin H. Prins and Marjolein Peters and Fletcher B. Taylor and Jan J M de Vijlder and Julia ten Cate and C. Erik Hack and Augueste Sturk},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={78 3},
  pages={1088-92}
}
Patients with sepsis or after major surgery have decreased plasma levels of the anticoagulant protein antithrombin. In such patients elevated levels of interleukin-6 (IL-6) are present and this interleukin is known to induce positive and negative acute phase responses. To investigate the possibility that antithrombin acts as a negative acute phase response-protein we performed studies on the human hepatoma cell line HepG2 in vitro and baboons in vivo. HepG2 cells were treated with recombinant… CONTINUE READING
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