Antithrombin III in patients with severe sepsis: a pharmacokinetic study

@article{Ilias2000AntithrombinII,
  title={Antithrombin III in patients with severe sepsis: a pharmacokinetic study},
  author={Wilfried K Ilias and William List and Johan Decruyenaere and Herv{\'e} Lignian and Sigurd Knaub and Fritz Schindel and Heinz Otto Keinecke and Hartmut Heinrichs and Lambert G. Thijs},
  journal={Intensive Care Medicine},
  year={2000},
  volume={26},
  pages={704-715}
}
Objectives: To evaluate the safety, pharmacokinetics, and the practicability of two different antithrombin III (AT III) high-dose regimens in patients with severe sepsis.¶Design: Prospective, open, randomized, 2 parallel groups, multinational clinical trial.¶Setting: Eleven academic medical center intensive care units (ICU) in Austria, Belgium, Denmark, Germany, Norway and Sweden.¶Patients: Thirty-three patients with severe sepsis who received standard supportive care and antimicrobial therapy… CONTINUE READING
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