Antithetic Integral Feedback Ensures Robust Perfect Adaptation in Noisy Biomolecular Networks.

The ability to adapt to stimuli is a defining feature of many biological systems and critical to maintaining homeostasis. While it is well appreciated that negative feedback can be used to achieve homeostasis when networks behave deterministically, the effect of noise on their regulatory function is not understood. Here, we combine probability and control… CONTINUE READING

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